2025/10/06 - Final HighVis Projcet Meeting at LBRG

Sun, 14 Dec 2025 14:21:43 +0100
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In August, the LBRG had the pleasure of welcoming Prof. Dr. Ferdinand le Noble and Dr. Dietmar Gradl from the Zoological Institute at KIT for the final HighVis project meeting.

The multidisciplinary HighVis project is funded by a ZEISS Collaboration Catalyst grant initiated by ZEISS Group and Karlsruher Institut für Technologie (KIT) and aligns with the research goals of the KIT Center Health Technologies .

In this project we propose a novel approach to measure blood viscosity based on in vivo intravital microscopic imaging of dynamic blood flows in the microcirculation, and subsequent computational analysis of microcirculatory red blood cell behavior.
Blood viscosity is an independent risk factor for predicting cardiovascular diseases including heart infarct and stroke. Routine assessment of blood viscosity can prevent progression to organ failure and subsequent premature mortality.Currently, fast, non-invasive techniques allowing repetitive measurement of viscosity in relevant patient populations are lacking, whereas existing ex-vivo techniques are cumbersome and not suitable for regular diagnostics.Our new algorithms developed in HighVis efficiently solve an inverse problem based on non-Newtonian Navier-Stokes models and deliver blood dynamics characteristics including viscosity.

A big thank you to the project group, Shota Ito, Ferdinand le Noble, Dietmar Gradl, Mathias J. Krause, and Stephan Simonis and our collaboration partners Gerd Klose, Ali Fard, Christian Kungel, and Sophia Schmitt, for their contributions and insights throughout this exciting project!

Stay tuned for upcoming publications and follow-up initiatives building on this work.